Chylomicron remnants bound to rabbit alveolar macrophages with high-affinity (Kd = 3.3 ± 0.71 μg of protein/mL). The metabolism of VLDL is very similar to that of chylomicrons, the major difference being that VLDL are assembled in hepatocytes to transport triglyceride containing fatty acids newly synthesized from excess glucose, or retrieved from the chylomicron remnants, to adipose tissue and muscle. This suggested the receptors were distinct. Let’s compare Chylomicrons with other terms. APOB48 and APOE are important for the identification of chylomicron remnants in the liver due to endocytosis and degradation. The VLDL receptor has been described as a new member of the LDL receptor supergene family that specifically binds VLDL in vitro via apolipoprotein E and lipoprotein lipase. Previous. Very low-density lipoprotein, or VLDL: Produced primarily by the liver, with smaller amounts contributed by the intestine. chylomicron remnants is influenced both by the fatty acid composition of the particles, and by longer-term adaptive changes in liver tissue, and suggest that the former effects are mediated mainly by the LDL receptor, while the latter may involve both the LDL receptor and the LRP. Less clear the signifi- cance of the LDL receptor in clearance chylo- micron remnants. The role of the LDL receptor in clearance of LDL is well established. J. Lipid &S. 1997. Information and translations of chylomicron remnants in the most comprehensive dictionary definitions resource on the web. THE low-density-lipoprotein (LDL) receptor is a cell-surface pro-tein that plays an important part in the metabolism of cholesterol by mediating the uptake of LDL from plasma into cells1. Therefore, it was suggested that the VLDL receptor may play a role in the uptake of chylomicron remnants in non-hepatic tissues [13]. In addition, while in the space of Disse chylomicron remnants can accumulate additional apoE that is secreted free into the space. Binding of chylomicron remnants and beta-very low density lipoproteins to hepatic and extrahepatic lipoprotein receptors. Definition of chylomicron remnants in the Definitions.net dictionary. The liver is the primary organ responsible for the clearance of pro-atherogeniclipoproteins, which include intermediate-density and low-density lipoproteins (IDL and LDL, respectively) and chylomicron remnants. 2 years ago | 08/07/2018 14:10:21 | gknowledge. Moreover, colchicine and monensin which are endocytotic and lysozomal inhibitors, respectively, did not have any effect on the degradation of chylomicron remnants by macrophages from normal rabbits. Several putative hepatic Although both the LDL receptor and the LRP have been implicated in the uptake of chylomicron remnants, it has been difficult to determine which, if either, plays the dominant role in this process. B. Apo B-48 specific. Science 264:1471–1474 CAS Chylomicron remnants are the post-hydrolytic product of intestinally derived chylo- microns, which are responsible for the transport of dietary lipid [2]. In previous studies, chylomicron remnants or chylomicron remnant‐like particles (CRLPs) have been shown to induce extensive lipid accumulation in a variety of macrophage types, including the murine macrophage cell line J774 [], mouse peritoneal macrophages [], primary human monocyte‐derived macrophages [[3, 4]] and macrophages derived from the human monocyte cell line THP‐1 [[4, 5, 19, 20]]. Uptake . 1 Answer +1 vote . remnants moved from the cell surface to the perinu-clear regions over this period (data not shown). Impaired clearance of chylomicron remnants correlates with increased vascular disease risk in FH. Fats and Fatty Acid Metabolism. Chylomicron remnants are enriched with endogenous TG fatty acids, compared with their parent chylomicrons, which consist primarily of exogenous TG fatty acids. Chylomicron Remnants Chylomicrons Apolipoprotein B-48 Lipoproteins, VLDL Receptors, LDL Lipoproteins Vitamin A Triglycerides Lymph Apolipoproteins E Liver Low Density Lipoprotein Receptor-Related Protein-1 Fetuins Apolipoproteins Corn Oil Cholesterol Emulsions Lipase Apolipoproteins B Cholesterol Esters Gold Colloid Lipoprotein Lipase Receptors, Lipoprotein Lactoferrin alpha … D. Apo E specific. chylomicron remnants might provide a useful means of detecting subtle changes in LDL receptor expression. [Google Scholar] Hui DY, Innerarity TL, Milne RW, Marcel YL, Mahley RW. When the lipoprotein remnants contact them they become bound and sequester (confined) against the hepatic cell membrane. This latter process allows the remnant to be taken up via the chylomicron remnant receptor. ical receptor for chylomicron remnants [13]. receptor is able to bind chylomicron remnants that are formed during the two-step pathway for chylomicron catabolism (1, 7). Keywords: chylomicron remnants; dietary fat; LDL recep- Receptors for chylomicron remnants are (A) Apo A specific (B) Apo B-48 specific (C) Apo C specific (D) Apo E specific . due, at least in part, to a loss of receptors which can recognize chylomicron remnants. Willnow TE, Sheng Z, Ishibashi S, Herz J (1994) Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. The loss of regulation of cholesterol synthesis by die- tary cholesterol (1) has been well documented in trans- plantable hepatomas (2), in primary hepatomas from several species including man (3,4) and in premalignant liver (5, 6). A. Apo A specific . The two substances did not compete with each other for removal by the isolated perfused rat liver. C. Apo C specific . The binding of chylomicron remnants was competitively inhibited in the presence of unlabeled remnants and to a lesser extent by unlabeled low-density lipoproteins. These data demonstrate that in the perfused livers of normal mice at physiological concentrations, remnants are effi-ciently internalized by receptor-mediated endocytosis. Chylomicron remnants can then be taken up by hepatocytes via interaction with the LDL receptor which requires apoE. 1982 Jan; 23 (1):42–52. Both apolipoprotein E and lipoprotein lipase are constituents of chylomicron remnants, another triglyceride-rich lipoprotein which has been proposed as a physiological ligand for the VLDL receptor. The publication costs of this article were defrayed in part by page charge payment. Unlabeled chylomicron remnants did not reduce the binding of 125 I-asiaglycoprotein to plasma membranes, but did compete for 125 I-chylomicron remanant binding. Lipoprotein-receptor related protein (LRP) requires apoE to facilitates the binding of the sequestered remnants to this receptor. Because enterocytes have the apolipoprotein B-100/E receptor, this study was directed at determining whether the cells can take up and metabolize chylomicron remnants and, if so, whether this was receptor mediated. chylomicron remnants is mediated at the surfaces ofparen- chymal liver cells by apolipoprotein B, E (LDL) receptors coded for by a single allelic pair of genes on chromosome 19 The converse also was true. VLDL contains relatively large amounts of triglycerides compared to protein. In rabbits, the VLDL receptor has been found predomi-nantly in heart, skeletal muscle, and adipose tissue, but not in the liver [14]. Chylomicron remnants were degraded by alveolar macrophages from Watanabe heritable hyperlipidemic (WHHL) rabbits, which are devoid of LDL receptor activity. The concentration of chylomicron remnants used for Meaning of chylomicron remnants. Even with statin treatment to lower LDL cholesterol, patients with diabetes have a high residual CVD risk. Next . Chylomicron: A lipoprotein rich in triglyceride and common in the blood during fat digestion and assimilation. "Chylomicron Remnants" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. What does chylomicron remnants mean? Both type 1 and type 2 diabetes increase the risk of atherosclerotic cardiovascular disease (CVD). 38 2173-2192. Moreover, it is impractical to use proper amounts of the tracer, because its tracee, chylomicron remnants, is virtually absent in the plasma of fasted mice (1, 34). Chylomicron remnants appear in the plasma only after fat ingestion, and never reach a steady state. This article must therefore be hereby marked "advertise- Moreover, a large number of people with prediabetes are at risk for developing frank diabetes worldwide. Supplementary key words chylomicron remnants chylomicron LDL receptor LDL receptor-related protein hepatic lipase heparan sulfate proteoglycan Consideration of lipoprotein metabolism has often been divided into endogenous and exogenous path- ways. Disse chylomicron remnants in the space of Disse chylomicron remnants of atherosclerotic cardiovascular disease ( CVD ) YL, RW. Dictionary definitions resource On the web apoE that is secreted free into the space hepatic the role the! 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